Chameleon Family

Chameleon Family

Chameleon lasers feature the widest tuning range and highest power at any wavelength, expanding the frontiers of Multiphoton Excitation (MPE) microscopy and non-linear optical studies.

New High Power Dual Wavelength Laser - Chameleon Discovery

The Chameleon Discovery is the newest ultrafast laser in the Chameleon Family.  Discovery is a high power dual wavelength laser offering the industry’s widest tuning range (680 nm to 1300 nm) and a short pulsewidth of 100 fs delivered directly to the sample plane. Applications include:

  • Multiphoton Excitation Microscopy
  • Second Harmonic Generation Imaging
  • Third Harmonic Generation Imaging
  • CARS/SRS Microscopy
  • Optogenetics
  • Ultrafast Spectroscopy
  • Non-linear Optics
More Than 2000 Chameleon Lasers Shipped World Wide.

Originally launch in 2003, the Chameleon family of Ti:Sapphire lasers are specifically designed for use in multphoton excitation (MPE) microscopy.

Growth in deep tissue MPE applications, along with the superior benefits and unmatched product reliability can be directly attributed to the success of the Chameleon lasers.

To learn more about Chameleon's reliability, performance and long distance trip to Antarctica, click on the links below:

Coherent's Chameleon - Receives the IOP Innovation Awards in 2013.

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Video provided by the Institute of Physics (IOP).

Welcome to the Chameleon Family— Ultimate Portfolio of Tunable Laser Sources for MPE

Multiphoton microscopy demands laser technology that is simple to use, yet flexible enough to allow you to explore the widest range of wavelengths and fluorophores. With the new release of the Chameleon Discovery, Coherent now truly offers the most powerful and flexible range of ultrafast technology designed for completely hands-off operation.

The Chameleon Ultra and Vision Series of Ti:Sapphire lasers are market proven performers and workhorses of the MPE community. With high average power and the widest tuning range (680-1080 nm), Chameleon Ultra delivers optical pulses with GVD characteristics matched to most commercial MPE microscopes. By incorporating our proprietary Power Pulse system, Chameleon can change color quickly (faster than 40 nm/s) whilst optimizing output power and pulse width automatically. And with the purpose-designed MRU air recirculator, Chameleon tunes effortlessly through atmospheric water vapor absorption lines, without the need for an external purge. Dependable as well as agile, Chameleon incorporates our field-proven Kerr lens modelocking technique, which is the most straightforward, reliable method for producing ultrafast pulses. Chameleon Vision lasers add dispersion compensation to deliver short pulses right to the sample plane, and the Vision-S, short pulse (75 fs) system, delivers higher peak power than any other automated tunable Ti:sapphire laser available.
The Chameleon MPX, is a wavelength extension that is pumped by Chameleon Ultra or Vision lasers and gives access to wavelengths up to 1340 nm.  Its unique dual tunablity capability enables powerful multimodal imaging techniques. The Chameleon Compact OPO and Compact OPO VIS extend the wavelength range of the Chameleon Ti:Sapphire laser from 240 nm to 4000 nm, for ultrafast spectroscopy and non-linear optics studies.
The NEW Chameleon Discovery is a high power, one-box, wide tuning range, dual output laser for MPE. Literally two lasers in one, it truly redefines the boundaries of what is possible for deep in-vivo imaging of all popular probes along with developing red shifted calcium indicators and opsins for optogenetics.
Chameleon lasers require only single-phase AC power, and no external cooling water. The result is a truly hands-off, virtually maintenance-free laser system, which allows you to put your focus exactly where it belongs—on your work.


Chameleon Discovery
Chameleon Discovery one-box, wide tuning range, dual output laser for MPE.
Chameleon Discovery Ultrafast Oscillator
Chameleon Compact OPO Family
Automated wavelength extension for Chameleon Ti:Sapphire lasers.
Chameleon Ultra Family
The flag ship of widely tunable, hands-free, modelocked Ti:Sapphire lasers.
Chameleon Ultra
Chameleon Vision Family
One-box laser solution with integrated precompensation.
Chameleon PreComp Accessory
Primarily designed for special microscope setups with high dispersion. 
Chameleon PreComp
Chameleon Family Specifications


Output Power (W)
Tuning Range (nm)
Chameleon Discovery
>1.3W at 900 nm
> 1.5W at 1040 nm
680 to 1300
Fixed 1040
Chameleon Ultra
>2.5 at 800 nm
690 to 1020

Chameleon Ultra I

>2.9 at 800 nm
690 to 1040

Chameleon Ultra II

>3.5 at 800 nm
680 to 1080

Chameleon Vision I

>2.5 at 800 nm
690 to 1040

Chameleon Vision II

>3.0 at 800 nm
680 to 1080

Chameleon Vision S

>2.3 at 800 nm
690 to 1050

Chameleon Compact OPO

>0.55 at 1100 nm
1000 to 1600

Chameleon MPX

>750 mW
1010 to 1340

Chameleon Compact OPO-Vis

>0.55 at 1100 nm
>0.11 at 550 nm
>1.4 at 400 nm
1000 to 1600
500 to 800
340 to 540

Chameleon PreComp

90% Transmission
Matches any Chameleon Ultra version



The Chameleon Advantage

The Chameleon Vision sets the benchmark for integrated precompensation. It uses a proprietary prism-based design that compensates the broadest range of GVD in a compact package. Traditional two-prism designs cannot deliver this same level of performance in such a small package size. This proprietary approach builds optimum beam pointing and stability into the design. It takes integrated precompensation to the next level offering the following advantages:

  • Highest output power: With more than 3 Watts, the Chameleon Vision offers the highest output power available from a laser with integrated precompensation.
  • Highest maximum negative dispersion: Many commercial microscopes now use acousto-optic devices introducing a considerable amount of pulse broadening. Home-built systems, designed for fast scanning for use with exotic lenses, may introduce the same effect. The new Chameleon Vision system is ideal to address these needs as its unique prism design adds up to 47,000 fs2 of negative dispersion usable to compensate your optical system. Chameleon Vision gives you dispersion compensation for the widest range of set-ups in order to deliver shorter pulses.
  • Highest dynamic range: The unique prism design enables you to vary the added negative dispersion over the full range - from maximum negative GVD down to 0 fs2 - without adding additional optics. This delivers peace of mind in flexibility for your setups.
  • Superior beam pointing: Chameleon Vision uses PermAlign™ technology (solder bonded optics) to mount all critical optical components. In combination with the unique prism design this provides unmatched beam pointing stability. This superior beam pointing stability translates into consistent images, scan after scan, sample after sample.
  • Widest tuning range: The widest tuning range of any integrated precompensation laser product providing the greatest flexibility in choice of fluorophores.
  • Fastest tuning: At 40 nm/s Chameleon has the fastest tuning speed on the market. A faster tuning range means that you can take images with different excitation wavelengths at a faster pace.
  • Lowest noise: The built-in single mode Verdi™ pump laser is key to Chameleon's reliability and low noise performance. Low noise from the excitation source means less variation in the excitation of each image pixel.

3D Video of MPE Mouse Brain image

800 micron deep brain img of mouse. Courtesy of Sara Crow, Drexel University

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